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A peptidomimetic is a small protein-like chain designed to mimic a peptide. [ 1 ] [ 2 ] They typically arise either from modification of an existing peptide, or by designing similar systems that mimic peptides, such as peptoids and β-peptides .
Murepavadin also known as POL7080 is a Pseudomonas specific peptidomimetic antibiotic. [1] It is a synthetic cyclic beta hairpin peptidomimetic based on the cationic antimicrobial peptide protegrin I (PG-1) and the first example of an outer membrane protein-targeting antibiotic class with a novel, nonlytic mechanism of action, highly active and selective against the protein transporter LptD of ...
Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with sequence CKGGRAKDC-GG-D (KLAKLAK) 2.It is an experimental proapoptotic drug [1] that has been shown to cause rapid weight loss in mice [2] and rhesus monkeys. [3]
A stapled peptide is a modified peptide (class A peptidomimetic), typically in an alpha-helical conformation, [2] that is constrained by a synthetic brace ("staple"). [3] The staple is formed by a covalent linkage between two amino acid side-chains, forming a peptide macrocycle. Staples, generally speaking, refer to a covalent linkage of two ...
6564 56643 Ensembl ENSG00000088386 ENSMUSG00000025557 UniProt P46059 Q9JIP7 RefSeq (mRNA) NM_005073 NM_053079 RefSeq (protein) NP_005064 NP_444309 Location (UCSC) Chr 13: 98.68 – 98.75 Mb Chr 14: 121.7 – 121.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse PepT 1 is a proton-coupled peptide cotransporter in epithelial cells. Peptide transporter 1 (PepT 1) also known as solute ...
A study on lipidation and PEGylation on the GLP-1 peptide was carried out and the results showed that lipidation had no significant effect on peptide activity in vitro, [31] whereas PEGylation did, especially when the PEG is attached to internal amino acids of the peptide e.g. positions 20 and 21. The reduction in activity from PEGylation ...
Such drug candidates increase the rate of glucose uptake in skeletal muscles and augment the rate of insulin secretion. [ 14 ] [ 15 ] Gruzman's group also developed new drug candidates against ALS . [ 16 ] [ 17 ] [ 18 ] His chemistry expertise is mainly related to peptide / peptidomimetic chemistry.
James Nowick is a professor of chemistry at University of California, Irvine.His research is focused on peptidomimetic (peptide-like) molecules and their potential applications to the study of amyloid-like protein aggregates, which are associated with neurodegenerative diseases such as Alzheimer's disease. [1]