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Grignard reagents or Grignard compounds are chemical compounds with the general formula R−Mg−X, where X is a halogen and R is an organic group, normally an alkyl or aryl. Two typical examples are methylmagnesium chloride Cl−Mg−CH 3 and phenylmagnesium bromide (C 6 H 5)−Mg−Br. They are a subclass of the organomagnesium compounds.
A solution of a carbonyl compound is added to a Grignard reagent. (See gallery) An example of a Grignard reaction (R 2 or R 3 could be hydrogen). The Grignard reaction (French:) is an organometallic chemical reaction in which, according to the classical definition, carbon alkyl, allyl, vinyl, or aryl magnesium halides (Grignard reagent) are added to the carbonyl groups of either an aldehyde or ...
This is a list of inorganic and organic reagents commonly used in chemistry. ... Grignard reagents: the most common application is for alkylation of aldehydes and ...
Examples of Grignard reagents are phenylmagnesium bromide and ethylmagnesium bromide. These simplified formulas are deceptive: Grignard reagents generally exist as dietherates, RMgX(ether)2. As such they obey the octet rule. Grignard reagents participate in the Schlenk equilibrium. Exploiting this reaction is a way to generate dimethylmagnesium.
Gilman reagent; Glaser coupling; Glycol cleavage; Goldberg reaction; Gomberg–Bachmann reaction; Gomberg–Bachmann–Hey reaction; Gomberg radical reaction; Gould–Jacobs reaction; Graebe–Ullmann synthesis; Grignard degradation; Griesbaum coozonolysis; Grignard reaction; Grob fragmentation; Grubbs' catalyst in Olefin metathesis; Grundmann ...
Like all Grignard reagents, propylmagnesium bromide is a strong electrophile, sensitive to both water and air. The propylmagnesium halides are the simplest Grignard reagents to exhibit isomerism. Isopropylmagnesium chloride is the primary synthetic equivalent of the isopropyl group. [1]
Grignard reagents can be obtained by reacting magnesium with halogenated hydrocarbons in a solvent. Since there is an oxide film on the surface of magnesium, iodine is generally added to accelerate the reaction. [3] Grignard reagents are commonly used in organic synthesis to extend carbon chains: [11]
The traditional method for generating the aryl Grignard reagent proceeds less predictably: slow, heterogeneous: XC 6 H 4 Br + Mg → XC 6 H 4 MgBr. Furthermore, traditional routes to Grignard reagents has limited functional group compatibility, whereas the Turbo-Grignard method tolerates other halides, some ester groups, and nitriles.
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