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Guanidine exists protonated, as guanidinium, in solution at physiological pH. Guanidinium chloride (also known as guanidine hydrochloride) has chaotropic properties and is used to denature proteins. Guanidinium chloride is known to denature proteins with a linear relationship between concentration and free energy of unfolding.
This dosage may be gradually increased to a total daily dosage of 35 mg/kg (16 mg/pound) of body weight per day or up to the development of side effects. Side effects may include increased peristalsis, diarrhea, paresthesia (tingling and numbness), and nausea. Fatal bone-marrow suppression, apparently dose related, can occur with guanidine. [7]
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.
“Urine has concentrated toxins in it, which is why your body is trying to get rid of it — and so what ends up happening is you want to hold the toxins in because they have a smell to them, and ...
Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug. [1] Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase.
A Fischer–Tropsch synthesis can also be used to form guanine, along with adenine, uracil, and thymine. Heating an equimolar gas mixture of CO, H 2 , and NH 3 to 700 °C for 15 to 24 minutes, followed by quick cooling and then sustained reheating to 100 to 200 °C for 16 to 44 hours with an alumina catalyst, yielded guanine and uracil:
The last of these is not pre-formulated, but rather is generated at the time of use by combining a cream containing calcium hydroxide (slaked lime) with an "activating solution" of guanidine carbonate. Another type of "no-lye" relaxer uses ammonium thioglycolate, which is also known as perm salt for its use in permanent waves.
Tetramethylguanidine is mainly used as a strong, non-nucleophilic base for alkylations, often as a substitute for the more expensive DBU and DBN. [3] Since it is highly water-soluble, it is easily removed from mixtures in organic solvents. It is also used as a base-catalyst in the production of polyurethane. [4]