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  2. Interferon-stimulated gene - Wikipedia

    en.wikipedia.org/wiki/Interferon-stimulated_gene

    An interferon-stimulated gene (ISG) is a gene that can be expressed in response to stimulation by interferon. [1] [2] Interferons bind to receptors on the surface of a cell, initiating protein signaling pathways within the cell. This interaction leads to the expression of a subset of genes involved in the innate immune system response. [1]

  3. ISG15 - Wikipedia

    en.wikipedia.org/wiki/ISG15

    Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. [ 5 ] [ 6 ] ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier.

  4. Interferome - Wikipedia

    en.wikipedia.org/wiki/Interferome

    Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). [1] These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated.

  5. Interferon - Wikipedia

    en.wikipedia.org/wiki/Interferon

    It took another fifteen to twenty years, using somatic cell genetics, to show that the interferon action gene and interferon gene reside in different human chromosomes. [71] [72] [73] The purification of human beta interferon did not occur until 1977. Y.H. Tan and his co-workers purified and produced biologically active, radio-labeled human ...

  6. Stimulator of interferon genes - Wikipedia

    en.wikipedia.org/wiki/Stimulator_of_interferon_genes

    Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. [ 5 ] STING plays an important role in innate immunity .

  7. Interferon alpha-1 - Wikipedia

    en.wikipedia.org/wiki/Interferon_alpha-1

    n/a Ensembl ENSG00000197919 n/a UniProt P01562 n/a RefSeq (mRNA) NM_024013 n/a RefSeq (protein) NP_076918 n/a Location (UCSC) Chr 9: 21.44 – 21.44 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma ; MIM 147570) is produced ...

  8. Interferon-alpha/beta receptor - Wikipedia

    en.wikipedia.org/wiki/Interferon-alpha/beta_receptor

    The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human type I IFNs include many subtypes, such as interferons-α, -β, -ε, -κ, -ω, and -ζ.

  9. IFNA2 - Wikipedia

    en.wikipedia.org/wiki/IFNA2

    The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 [8] and as all type I IFN genes, it is devoid of intron. [9] The open reading frame (coding sequence) of IFNA2 codes for a pre-protein of 188 amino acids with a 23 amino acid signal peptide allowing secretion of the mature protein.