Ad
related to: drugs that damage the liver and heart muscle development occurs due- 262 Neil Avenue # 430, Columbus, Ohio · Directions · (614) 221-7464
- Should I See A Heart Doc
Talk to your doc about your heart
and learn what to ask
- Find a Doctor
Meet with our experts to diagnose
your symptoms and receive treatment
- Prepare For Your Visit
What to bring to your visit
plus heart & vascular resources
- Patient Testimonials
Hear from our patients
about their Ohio State experience
- Should I See A Heart Doc
Search results
Results from the WOW.Com Content Network
First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.
Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
ACM is a type of heart disease that occurs due to chronic alcohol consumption. The etiology of ACM is multifactorial, with a combination of genetic, environmental, and lifestyle factors playing a role. [2] The direct toxic effects of alcohol on the heart muscle cells (cardiomyocytes) are considered the primary cause of ACM. [2]
HRS can affect individuals with cirrhosis, severe alcoholic hepatitis, or liver failure, and usually occurs when liver function deteriorates rapidly because of a sudden insult such as an infection, bleeding in the gastrointestinal tract, or overuse of diuretic medications. HRS is a relatively common complication of cirrhosis, occurring in 18% ...
The muscle damage is most usually caused by a crush injury, strenuous exercise, medications, or a substance use disorder. [3] Other causes include infections , electrical injury , heat stroke , prolonged immobilization, lack of blood flow to a limb , or snake bites [ 3 ] as well as intense or prolonged exercise, particularly in hot conditions ...
Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity. [1] This can cause heart failure, arrhythmia, myocarditis, and cardiomyopathy in patients. [2] Some effects are reversible, while in others, permanent damage requiring further treatment may arise.
Chagas disease, due to Trypanosoma cruzi. This is the most common infectious cause of dilated cardiomyopathy in Latin America [17] Pregnancy: Dilated cardiomyopathy occurs late in gestation or several weeks to months postpartum as a peripartum cardiomyopathy. [14] It is reversible in half of cases. [14] Alcohol use disorder (alcoholic ...
An excess of free fatty acids in liver cells plays a role in Nonalcoholic Fatty Liver Disease (NAFLD). In the liver, it is the type of fatty acid, not the quantity, that determines the extent of the lipotoxic effects. In hepatocytes, the ratio of monounsaturated fatty acids and saturated fatty acids leads to apoptosis and liver damage. There ...
Ad
related to: drugs that damage the liver and heart muscle development occurs due- 262 Neil Avenue # 430, Columbus, Ohio · Directions · (614) 221-7464