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Augmentin 250, for example, contains 250 mg of amoxicillin and 125 mg of clavulanic acid. [ 12 ] [ 27 ] An intravenous preparation has been available in the UK since 1985, [ 28 ] but no parenteral preparation is available in the US; [ citation needed ] the nearest equivalent is ampicillin/sulbactam .
The process mainly involves 3 enzymes: clavaminate synthase, β-lactam synthetase, and N 2-(2-carboxyethyl)-L-arginine (CEA) synthase. [10] Clavaminate synthase is a non-heme oxygenase dependent on iron and α-keto-glutarate and is encoded by orf5 of the clavulanic acid gene cluster. The specific mechanism of how this enzyme works is not fully ...
Children with acute otitis media who are younger than six months of age are generally treated with amoxicillin or other antibiotics. Although most children with acute otitis media who are older than two years old do not benefit from treatment with amoxicillin or other antibiotics, such treatment may be helpful in children younger than two years old with acute otitis media that is bilateral or ...
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GBS-EOD manifests from 0 to 7 living days in the newborn, with most of the cases of EOD being apparent within 24 h from birth. GBS-LOD starts between 7 and 90 days after birth. [ 4 ] [ 12 ] [ 14 ] [ 22 ] Roughly 50% of newborns of GBS-colonized mothers are also GBS-colonized and (without prevention measures) 1-2% of these newborns will develop ...
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MYCIN was an early backward chaining expert system that used artificial intelligence to identify bacteria causing severe infections, such as bacteremia and meningitis, and to recommend antibiotics, with the dosage adjusted for patient's body weight — the name derived from the antibiotics themselves, as many antibiotics have the suffix "-mycin".