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In females, the paramesonephric ducts give rise to the uterine tubes, uterus, and upper portion of the vagina, while the mesonephric ducts degenerate due to the absence of male androgens. In contrast, the paramesonephric ducts begin to proliferate and differentiate in a cranial-caudal progression to form the aforementioned structures.
The internal genitalia consist of two accessory ducts: mesonephric ducts (male) and paramesonephric ducts (female). The mesonephric system is the precursor to the male genitalia and the paramesonephric to the female reproductive system. [8] As development proceeds, one of the pairs of ducts develops while the other regresses.
In the male, the paramesonephric ducts atrophy (but traces of their anterior ends are represented by the appendix of testis of the male), while their terminal fused portions form the prostatic utricle in the floor of the prostatic urethra. This is due to the production of anti-Müllerian hormone by the Sertoli cells of the testes.
m, m. Right and left Müllerian ducts uniting together and running with the Wolffian ducts in gc, the genital cord: m. Müllerian duct, the upper part of which remains as the hydatid of Morgagni; the lower part, represented by a dotted line descending to the prostatic utricle, constitutes the occasionally existing cornu and tube of the uterus ...
The prostatic utricle is a remnant that is homologous to the female uterus (including the cervix) and vagina, usually described as derived from the paramesonephric ducts, [9] although this is occasionally disputed. [10]
In the mature male, the function of this system is to store and mature sperm, and provide accessory semen fluid.The mesonephric duct (precursor of the male reproductive system) forms around the 3-4th week of pregnancy, present before the paramesonephric duct (precursor of the female reproductive system).
The condition occurs in males and consists of normal-functioning reproductive organs and gonads, but also female reproductive organs such as the uterus and the fallopian tubes. The fetus has two sets of tubes which give rise to accessory reproductive organs - the (Wolffian) mesonephric ducts and the (Müllerian) paramesonephric ducts. Usually ...
The developing tubules within the testes secretes a polypeptide Müllerian inhibition factor (MIF). MIF causes the regression of the paramesonephritic ducts 60 days after fertilization. Testosterone secretion by the interstitial cells of the testes then causes the growth and development of the mesonephric ducts into male secondary sex organs. [7]