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The gut–brain–liver axis and gut microbiota composition can regulate the glucose homeostasis in the liver and provide potential therapeutic methods to treat obesity and diabetes. [ 159 ] Just as gut flora can function in a feedback loop that can drive the development of obesity, there is evidence that restricting intake of calories (i.e ...
Furthermore, administration of antibiotics to rodents alters gut microbiota composition and ensuing changes in gut hormone levels are also detected. These results may provide the mechanistic explanation for the claim that antibiotics can lead to obesity in humans. Yet, whether these findings can be replicated in human studies remains to be seen ...
Bacteriotherapy is the purposeful use of bacteria or their products in treating an illness. [1] Forms of bacteriotherapy include the use of probiotics, microorganisms that provide health benefits when consumed; fecal matter transplants (FMT) [2] /intestinal microbiota transplant (IMT), [3] the transfer of gut microorganisms from the fecal matter of healthy donors to recipient patients to ...
The bidirectional communication between the gut and the brain incorporates signals from trillions of gut microbes collectively known as the intestinal microbiota and affects a plethora of ...
In 2009, the largest human study concerning obesity and gut microbiota to date was conducted. Obesity disorders are the result of an imbalance and have serious consequences such as cardiovascular disease, type 2 diabetes, and colon cancer. The gut microbiota and environment contributes to the energy imbalance because of its involvement in ...
Studies of gut microbiota have found indications that higher levels of B. wexlerae may decrease obesity in mice and humans. [3] B. wexlerae produces acetylcholine and carbohydrate metabolites (ex. succinate, lactate, acetate). These may modify the gut environment, including the bacterial and SCFA composition of the gut microbiota.
Obesity medicine is a field of medicine dedicated to the comprehensive treatment of patients with obesity. Obesity medicine takes into account the multi-factorial etiology of obesity in which behavior, development, environment, epigenetic , genetic , nutrition , physiology , and psychosocial contributors all play a role. [ 1 ]
The gut microbiota, which is a population of microbes that live in the human digestive system, also has an important part in metabolism and generally has a positive function for its host. In terms of pathophysiological/mechanism interactions, an abnormal gut microbiota can play a role in metabolic disorder related obesity. [8]
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