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  2. GABA receptor - Wikipedia

    en.wikipedia.org/wiki/GABA_receptor

    A subclass of ionotropic GABA receptors, insensitive to typical allosteric modulators of GABA A receptor channels such as benzodiazepines and barbiturates, [27] [28] [29] was designated GABA С receptor. [30] [31] Native responses of the GABA C receptor type occur in retinal bipolar or horizontal cells across vertebrate species. [32] [33] [34] [35]

  3. GABAA receptor - Wikipedia

    en.wikipedia.org/wiki/GABAA_receptor

    The ionotropic GABA A receptor protein complex is also the molecular target of the benzodiazepine class of tranquilizer drugs. Benzodiazepines do not bind to the same receptor site on the protein complex as does the endogenous ligand GABA (whose binding site is located between α- and β-subunits), but bind to distinct benzodiazepine binding sites situated at the interface between the α- and ...

  4. GABAB receptor - Wikipedia

    en.wikipedia.org/wiki/GABAB_receptor

    GABA B Receptors are similar in structure to and in the same receptor family with metabotropic glutamate receptors. [10] There are two subunits of the receptor, GABA B1 and GABA B2, [11] and these appear to assemble as obligate heterodimers in neuronal membranes by linking up by their intracellular C termini. [10]

  5. GABA receptor agonist - Wikipedia

    en.wikipedia.org/wiki/GABA_receptor_agonist

    Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1] There are three receptors of the gamma-aminobutyric acid. The ...

  6. GABA transporter - Wikipedia

    en.wikipedia.org/wiki/GABA_transporter

    These changes rely on the precise timing of GABA receptors activation which in turn are dependent upon the release and clearance of GABA in the extracellular space. This reuptake of neurotransmitters plays a significant role in the overall process of synaptic transmission.

  7. Presynaptic inhibition - Wikipedia

    en.wikipedia.org/wiki/Presynaptic_inhibition

    Primary sensory afferents contain GABA receptors along their terminals (reviewed in:, [13] Table 1). GABA receptors are ligand-gated chloride channels, formed by the assembly of five GABA receptor subunits. In addition to the presence of GABA receptors along sensory afferent axons, the presynaptic terminal also has a distinct ionic composition ...

  8. GABAA receptor positive allosteric modulator - Wikipedia

    en.wikipedia.org/wiki/GABAA_receptor_positive...

    In pharmacology, GABA A receptor positive allosteric modulators, also known as GABAkines or GABA A receptor potentiators, [1] are positive allosteric modulator (PAM) molecules that increase the activity of the GABA A receptor protein in the vertebrate central nervous system. GABA is a major inhibitory neurotransmitter in the central nervous system.

  9. Ionotropic GABA receptor - Wikipedia

    en.wikipedia.org/wiki/Ionotropic_GABA_receptor

    The GABA B receptor, a G protein-coupled receptor, is the only metabotropic GABA receptor and its mechanism of action differs significantly from the ionotropic receptors. Functionally, in mature organisms, activation of these receptors typically results in neural inhibition, primarily via the influx of chloride ions , although exceptions to ...