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Elevated alpha-fetoprotein refers to a state where alpha-fetoprotein levels are outside of the reference range. There are two categories of AFP tests: tests performed on serum (blood plasma), and tests performed on amniotic fluid. Tests performed on serum are further categorized by the reason for performing the test: maternal serum, adult tumor ...
Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein [5] [6] that in humans is encoded by the AFP gene. [ 7 ] [ 8 ] The AFP gene is located on the q arm of chromosome 4 (4q13.3). [ 9 ]
Alpha fetoprotein (AFP) 44 [15] ng/mL or μg/L: Hepatocellular carcinoma or testicular cancer Beta human chorionic gonadotrophin (β-hCG) In males and non-pregnant females: 5 [15] IU/L or mU/mL: choriocarcinoma CA19-9: 40 [15] U/mL: Pancreatic cancer CA-125: 30, [71] 35 [72] kU/L or U/mL: Carcinoembryonic antigen (CEA) Non-smokers, 50 years: 3. ...
Tumor marker Associated tumor types Alpha fetoprotein (AFP) germ cell tumor, hepatocellular carcinoma [8] CA15-3: breast cancer [9] CA27.29: breast cancer [10] CA19-9: Mainly pancreatic cancer, but also colorectal cancer and other types of gastrointestinal cancer. [11] CA-125
In pregnant people AFP levels rise at 14 weeks until 32 weeks, and range between 10 and 150 ng/mL in the middle of gestation. This is why AFP can be used alongside other tests as a tumor marker protein in adults. [12] AFP is a single polypeptide chain with a half-life of 4–5 days.
High levels of alpha-fetoprotein (AFP) in the blood can be found in many cases of HCC and intrahepatic cholangiocarcinoma. Cholangiocarcinoma can be detected with these commonly used tumor markers: carbohydrate antigen 19-9 (CA 19–9), carcinoembryonic antigen (CEA) and cancer antigen 125 . These tumour markers are found in primary liver ...
Pages in category "Tumor markers" ... AFP-L3; Alpha-fetoprotein; Alpha-methylacyl-CoA racemase; B. BRCA1; BRCA2; C. CA 15-3; CA 27-29; CA 242 (tumor marker) CA19-9 ...
AFP-L3% is the standard for quantifying the L3 isoform of AFP in serum of high risk chronic liver disease (CLD) patients. Studies have shown that AFP-L3% test results of more than 10% can be indicative of early HCC [ citation needed ] or early nonseminomatous germ cell tumor .