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Midazolam is poorly absorbed orally, with only 50% of the drug reaching the bloodstream. [16] Midazolam is metabolised by cytochrome P450 (CYP) enzymes and by glucuronide conjugation. Oxidation of midazolam is the major metabolite in human liver microsome (HLM). [68] The half life (t 1 ⁄ 2) of midazolam in HLM is 3.3 minutes. [68]
In medicine, specifically in end-of-life care, palliative sedation (also known as terminal sedation, continuous deep sedation, or sedation for intractable distress of a dying patient) is the palliative practice of relieving distress in a terminally ill person in the last hours or days of a dying person's life, usually by means of a continuous intravenous or subcutaneous infusion of a sedative ...
The Liverpool Care Pathway for the Dying Patient (LCP) was a care pathway in the United Kingdom (excluding Wales) covering palliative care options for patients in the final days or hours of life. It was developed to help doctors and nurses provide quality end-of-life care, to transfer quality end-of-life care from the hospice to hospital ...
The elimination half-life is how long it takes for half of the drug to be eliminated by the body. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose.
Midazolam is considered a first line agent in palliative sedation therapy during the last weeks of life to alleviate intolerable suffering unresponsive to other treatments Whilst this is true (and referenced), it seems to me it gives a misleading impression of how midazolam is typically used in end of life care.
This story includes graphic descriptions of crimes committed against a young girl. Oklahoma executed Kevin Ray Underwood on Thursday for killing a 10-year-old girl in April 2006, making him the ...
It also provides for a secondary fail-safe measure using intramuscular injection of midazolam, followed by sufentanil or hydromorphone in the event intravenous administration of the sodium thiopental proves problematic. [54] The first state to switch to use midazolam as the first drug in a new three-drug protocol was Florida on October 15, 2013 ...
Midazolam – It is a fast-acting and the most lipophilic of all benzodiazepine and rapidly crosses the blood–brain barrier. It is a gamma-aminobutyric acid (GABA) agonist. [9] Usual doses for midazolam are 1 mg to 2 mg where the older people receive smaller doses and obese people receive higher doses.