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A single kidney stone in children or recurrent stones in adults is often the first warning sign of primary hyperoxaluria. Other symptoms range from recurrent urinary tract infections , severe abdominal pain or pain in the side, blood in the urine , to chronic kidney disease and kidney failure . [ 1 ]
A kidney stone (yellow) composed of calcium oxalate, next to a tourmaline gemstone for scale. Calcium is one component of the most common type of human kidney stones, calcium oxalate. Some studies suggest that people who take calcium or vitamin D as a dietary supplement have a higher risk of developing kidney stones.
A favorable outcome is more likely if a kidney transplant is complemented by a liver transplant, given the disease originates in the liver. [citation needed] Secondary hyperoxaluria is much more common than primary hyperoxaluria, and should be treated by limiting dietary oxalate and providing calcium supplementation. [citation needed]
About 76% of kidney stones are partially or entirely of the calcium oxalate type. [6] They form when urine is persistently saturated with calcium and oxalate. Between 1% and 15% of people globally are affected by kidney stones at some point. [14] [15] In 2015, they caused about 16,000 deaths worldwide. [16]
In kidney stones, calcium oxalate is the most common mineral type (see nephrolithiasis). Uric acid is the second most common mineral type, but an in vitro study showed uric acid stones and crystals can promote the formation of calcium oxalate stones.
The term nephrocalcinosis is used to describe the deposition of both calcium oxalate and calcium phosphate. [1] It may cause acute kidney injury. It is now more commonly used to describe diffuse, fine, renal parenchymal calcification in radiology. [2] It is caused by multiple different conditions and is determined by progressive kidney dysfunction.
In December 2003, a kidney stone weighing 356 g (12.5 oz) was removed from the right kidney of Peter Baulman of Australia. At its widest point, the stone measured 11.86 cm (4.66 in). [ 9 ] In 2017, a 2 kg (4.4 lb) stone spanning 20 cm was surgically removed from Abdul Abu Al Hajjar in Kensington , England.
Oxalate (systematic IUPAC name: ethanedioate) is an anion with the chemical formula C 2 O 2− 4.This dianion is colorless. It occurs naturally, including in some foods. It forms a variety of salts, for example sodium oxalate (Na 2 C 2 O 4), and several esters such as dimethyl oxalate ((CH 3) 2 C 2 O 4).
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