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A trough level is contrasted with a "peak level" (C max), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It is widely used in clinical trials for newer medicines to investigate therapeutic effectiveness and safety.
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
That immediately gets the drug's concentration in the body up to the therapeutically-useful level. First day: 1000 mg; the body clears 100 mg, leaving 900 mg. On the second day, the patient takes 100 mg, bringing the level back to 1000 mg; the body clears 100 mg overnight, still leaving 900 mg, and so forth.
Depending on context, wave height may be defined in different ways: For a sine wave, the wave height H is twice the amplitude (i.e., the peak-to-peak amplitude): [1] =.; For a periodic wave, it is simply the difference between the maximum and minimum of the surface elevation z = η(x – c p t): [1] = {()} {()}, with c p the phase speed (or propagation speed) of the wave.
Significant wave height H m0, defined in the frequency domain, is used both for measured and forecasted wave variance spectra.Most easily, it is defined in terms of the variance m 0 or standard deviation σ η of the surface elevation: [6] = =, where m 0, the zeroth-moment of the variance spectrum, is obtained by integration of the variance spectrum.
Trough (geology), a long depression less steep than a trench; Trough (meteorology), an elongated region of low atmospheric pressure; Trough (physics), the lowest point on a wave; Trough level (medicine), the lowest concentration of a medicine is present in the body over time; Langmuir-Blodgett trough, a laboratory instrument
A trough is an elongated area of lower air pressure. Since pressure is closely linked to wind, there are often changes in wind direction across a trough. If a trough forms in the mid-latitudes, a temperature difference at some distance between the two sides of the trough usually exists and the trough might become a weather front at some
The peak-to-average power ratio (PAPR) is the peak amplitude squared (giving the peak power) divided by the RMS value squared (giving the average power). [1] It is the square of the crest factor. When expressed in decibels , crest factor and PAPR are equivalent, due to the way decibels are calculated for power ratios vs amplitude ratios .