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  2. Missense mutation - Wikipedia

    en.wikipedia.org/wiki/Missense_mutation

    Missense mutations in the MeCP2 protein can cause Rett syndrome, otherwise known as the RTT phenotype [7]. T158M, R306C and R133C are the most common missense mutations causing RTT [7]. T158M is a mutation of an adenine being substituted for a guanine causing the threonine at amino acid position 158 being substituted with a methionine [8].

  3. Single-nucleotide polymorphism - Wikipedia

    en.wikipedia.org/wiki/Single-nucleotide_polymorphism

    An important group of SNPs are those that corresponds to missense mutations causing amino acid change on protein level. Point mutation of particular residue can have different effect on protein function (from no effect to complete disruption its function). Usually, change in amino acids with similar size and physico-chemical properties (e.g ...

  4. Nonsynonymous substitution - Wikipedia

    en.wikipedia.org/wiki/Nonsynonymous_substitution

    Nonsense mutations are nonsynonymous substitutions that arise when a mutation in the DNA sequence causes a protein to terminate prematurely by changing the original amino acid to a stop codon. Another type of mutation that deals with stop codons is known as a nonstop mutation or readthrough mutation, which occurs when a stop codon is exchanged ...

  5. Point accepted mutation - Wikipedia

    en.wikipedia.org/wiki/Point_accepted_mutation

    The missense mutations may be classed as point accepted mutations if the mutated protein is not rejected by natural selection. A point accepted mutation — also known as a PAM — is the replacement of a single amino acid in the primary structure of a protein with another single amino acid, which is accepted by the processes of natural selection.

  6. Amino acid replacement - Wikipedia

    en.wikipedia.org/wiki/Amino_acid_replacement

    Amino acid replacement is a change from one amino acid to a different amino acid in a protein due to point mutation in the corresponding DNA sequence. It is caused by nonsynonymous missense mutation which changes the codon sequence to code other amino acid instead of the original. Notable mutations

  7. Point mutation - Wikipedia

    en.wikipedia.org/wiki/Point_mutation

    In molecular biology, repeat-induced point mutation or RIP is a process by which DNA accumulates G:C to A:T transition mutations. Genomic evidence indicates that RIP occurs or has occurred in a variety of fungi [ 20 ] while experimental evidence indicates that RIP is active in Neurospora crassa , [ 21 ] Podospora anserina , [ 22 ] Magnaporthe ...

  8. Transversion - Wikipedia

    en.wikipedia.org/wiki/Transversion

    Illustration of a transversion: each of the 8 nucleotide changes between a purine and a pyrimidine (in red). The 4 other changes are transitions (in blue).. Transversion, in molecular biology, refers to a point mutation in DNA in which a single (two ring) purine (A or G) is changed for a (one ring) pyrimidine (T or C), or vice versa. [1]

  9. Mutation - Wikipedia

    en.wikipedia.org/wiki/Mutation

    Download as PDF; Printable version; ... In biology, a mutation is an alteration in the nucleic acid ... if a missense mutation occurs in an amino acid codon that ...