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14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 200 signaling proteins have been reported as 14-3-3 ligands.
22629 Ensembl ENSG00000128245 ENSMUSG00000018965 UniProt Q04917 P68510 RefSeq (mRNA) NM_003405 NM_011738 RefSeq (protein) NP_003396 NP_035868 Location (UCSC) Chr 22: 31.94 – 31.96 Mb Chr 5: 33.18 – 33.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 14-3-3 protein eta also referred to as 14-3-3η is a protein that in humans is encoded by the YWHAH gene. Function This gene ...
All together, the 14-3-3 protein may have a significant role in respiratory function and NRDS. [25] [26] Furthermore, recent studies have shown the 14-3-3ζ plays a significant clinical role in the suppression of the RA symptoms in experimental animals. The 14-3-3ζ KO animals had early onset and severe inflammatory arthritis compared to wild-type.
It also functions as a recruiting factor that localizes dynein to where it should be. [ 31 ] [ 32 ] There is also some evidence suggesting that it may regulate kinesin-2. [ 33 ] The dynactin complex is composed of more than 20 subunits, [ 29 ] of which p150(Glued) is the largest. [ 34 ]