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Detomidine is a sedative with analgesic properties. [3] α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters.
The Dosage Index is a mathematical figure used by breeders of Thoroughbred race horses, and sometimes by bettors handicapping horse races, to quantify a horse's ability, or inability, to negotiate the various distances at which horse races are run. It is calculated based on an analysis of the horse's pedigree.
A Dosage Index of under 4.00 is considered optimal for horses attempting to win classic races. [7] As the Dosage Profile and Index are widely published, breeders may select mates for their mare with these figures in mind, especially if they are intending to sell the foal at auction.
Calciseptine has been shown to specifically inhibit the L-type voltage-gated Ca 2+ channels and was the first natural polypeptide discovered with this property. Specific polypeptide inhibitors of voltage-sensitive channels are important tools in research, and were already known for voltage-sensitive Na + channels, both voltage-sensitive and Ca 2+-activated K + channels, and for N-type Ca 2 ...
Continuous dewormers are a mild low dose and may be easier on the horse, but may not be effective in quickly killing worms in a heavily-infected horse and may contribute to drug resistance. If a treatment doesn't kill at least 95% of a worm species, that species is classed as 'resistant' to the drug.
Health insurance industry officials remain uncharacteristically reserved in the aftermath of the fatal shooting of UnitedHealthcare CEO Brian Thompson on Dec. 4.. A week after the attack, the ...
Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt.In the United States, it is regulated by the U.S. Food and Drug Administration (FDA), and may only be lawfully distributed by order of a licensed veterinarian.
Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses, [1] although it may be used in a wide variety of species. [2] [3] It is not used in humans, but is closely related in structure to the commonly used drug clonidine. Romifidine acts as an agonist at the α 2 adrenergic receptor subtype.