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Lassa virus life cycle. Figure by Fehling et al., 2012 [13] The life cycle of Lassa mammarenavirus is similar to the Old World arenaviruses. Lassa mammarenavirus enters the cell by the receptor-mediated endocytosis. Which endocytotic pathway is used is not known yet, but at least the cellular entry is sensitive to cholesterol depletion.
Lassa fever, also known as Lassa hemorrhagic fever, is a type of viral hemorrhagic fever caused by the Lassa virus. [1] Many of those infected by the virus do not develop symptoms . [ 1 ] When symptoms occur they typically include fever , weakness, headaches, vomiting , and muscle pains . [ 1 ]
An arenavirus is a bi- or trisegmented ambisense RNA virus that is a member of the family Arenaviridae. [1] [2] These viruses infect rodents and occasionally humans.A class of novel, highly divergent arenaviruses, properly known as reptarenaviruses, have also been discovered which infect snakes to produce inclusion body disease, mostly in boa constrictors.
The virus is normally carried by infected rodents and spread to humans through contact with urine or droppings ... Between 100,000 to 300,000 cases of Lassa fever are diagnosed per annum. Roughly ...
Lassa fever is "an acute viral hemorrhagic illness caused by Lassa virus," according to the World Health Organization. "Lassa fever is a potentially life-threatening viral disease," Dr. Albert Ko ...
Lassa, CCHF, Ebola, and Marburg viruses may be particularly prone to nosocomial (hospital-based) spread. Airborne precautions should be utilized including, at a minimum, a fit-tested , HEPA filter-equipped respirator (such as an N95 mask ), a battery-powered, air-purifying respirator, or a positive pressure supplied air respirator to be worn by ...
Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is ...
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