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Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant (TCA). [7] It is used in the treatment of various conditions, most notably obsessive–compulsive disorder but also many other disorders, including hyperacusis, panic disorder, major depressive disorder, trichotillomania, [8] body dysmorphic disorder [9] [10] [11] and chronic pain. [7]
ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
The term seizure threshold is used to describe the balance between excitatory (glutaminergic) and inhibitory (GABA-ergic) forces in the brain which affect how susceptible a person is to seizures. Those diagnosed with epilepsy or certain other neurological conditions are more vulnerable to seizures if the threshold is reduced, and should be ...
Status epilepticus is a seizure "lasting longer than 30 minutes or a series of seizures without return to the baseline level of alertness between seizures." [ 12 ] Epilepsia partialis continua is a rare type of focal motor seizure, commonly involving the hands or face , which recurs with intervals of seconds or minutes, lasting for extended ...
Seizures typically occur within the first two years of life and are refractory in nearly half of cases. [80] However, high rates of seizure freedom with surgery have been reported in as many as 83%. [81] Neurofibromatosis type 1 is the most common phakomatoses and occurs in approximately 1 in 3,000 live births. [82]
[3] [8] If a seizure lasts longer than 5 minutes, it is a medical emergency (status epilepticus) and needs immediate treatment. [3] [5] [9] Seizures can be classified as provoked or unprovoked. [3] [6] Provoked seizures have a cause that can be fixed, such as low blood sugar, alcohol withdrawal, high fever, recent stroke, and recent head trauma.
A generalized tonic–clonic seizure, commonly known as a grand mal seizure or GTCS, [1] is a type of generalized seizure that produces bilateral, convulsive tonic and clonic muscle contractions. Tonic–clonic seizures are the seizure type most commonly associated with epilepsy and seizures in general and the most common seizure associated ...