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Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United States in 1978. [7] It is available as a generic medication. [12] In 2022, it was the 254th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Alfacalcidol (or 1-hydroxycholecalciferol) is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive.. Alfacalcidol has a weaker impact on calcium metabolism [3] and parathyroid hormone levels [4] than calcitriol; but significant effects on the immune system, including regulatory T cells. [5]
These properties may be beneficial in people with intestinal malabsorption, obesity, or treated with certain other medications. [ 20 ] In 2016, the FDA approved a formulation of calcifediol (Rayaldee) 60 microgram daily as a prescription medication to treat secondary hyperparathyroidism in patients with chronic kidney disease .
Preferred drugs (and other treatments) are also referred to a "first line" or "primary" while others are called "second line", "third line" etc. [7] [8] A drug may be indicated as an "adjunct" or "adjuvant", added to a first line drug. [9] Off-label: Off-label indications are drugs that are used for medical indications that have not been ...
Indications [1] [2] [4] Major toxicities [1] [2] [4] [5] 1. Cytotoxic antineoplastics: 1.01 Nucleoside analogues: Azacitidine: SC, IV: DNA methyltransferase inhibitor and incorporates itself into RNA, hence inhibiting gene expression. [6] Myelodysplastic syndromes, acute myeloid leukaemia and chronic myeloid leukaemia
Hydroxycarbamide is in the antineoplastic family of medications. It is believed to work by blocking the making of DNA. [4] Hydroxycarbamide was approved for medical use in the United States in 1967. [4] It is on the World Health Organization's List of Essential Medicines. [6] Hydroxycarbamide is available as a generic medication. [4]
Commonly used tocolytic medications include β 2 agonists, calcium channel blockers, NSAIDs, and magnesium sulfate. These can assist in delaying preterm delivery by suppressing uterine muscle contractions and their use is intended to reduce fetal morbidity and mortality associated with preterm birth. [ 2 ]
Drugs that may decrease the levels or activity of endogenous steroid hormones, e.g. cimetidine, ketoconazole, and spironolactone Additional medications for high cholesterol such as clofibrate , fenofibrate , gemfibrozil , and niacin (when taken in lipid-modifying doses of 1 g/day and above)
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