Search results
Results from the WOW.Com Content Network
Nonsense mutations comprise around 20% of single nucleotide substitutions within protein coding sequences that result in human disease. [12] Nonsense mutation-mediated pathology is often attributed to reduced amounts of full-length protein, because only 5-25% of transcripts possessing nonsense mutations do not undergo nonsense-mediated decay (NMD).
Literary nonsense, as recognized since the nineteenth century, comes from a combination of two broad artistic sources. The first and older source is the oral folk tradition, including games, songs, dramas, and rhymes, such as the nursery rhyme "Hey Diddle Diddle". [3]
Nonsense suppressors are a useful genetic tool, but can also result in problematic side effects, since all identical stop codons in the genome will also be suppressed to the same degree. Genes with different or multiple stop codons will be unaffected. SUP35, a nonsense suppressor identified by Wickner in 1994, is a prion protein.
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons . [ 1 ]
Nonsense may also mean: Abstract nonsense, a term used by mathematicians to describe certain kinds of arguments and concepts in category theory; Nonsense mutation, a term in genetics for a point mutation in a sequence of DNA that results in a premature stop codon; Nonsense verse "Nonsense", a song by Madeon featuring Mark Foster, from the album ...
Two other types of nonsynonymous substitution are the nonsense mutations, in which a codon is changed to a premature stop codon that results in truncation of the resulting protein, and the nonstop mutations, in which a stop codon erasement results in a longer, nonfunctional protein.
Nonsense verse is the verse form of literary nonsense, a genre that can manifest in many other ways. Its best-known exponent is Edward Lear, author of The Owl and the Pussycat and hundreds of limericks. Nonsense verse is part of a long line of tradition predating Lear: the nursery rhyme Hey Diddle Diddle could also
A nonsense song is a type of song written mainly for the purpose of entertainment using nonsense syllables at least in the chorus. Such a song generally has a simple melody and a quick (or fairly quick) tempo and repeating sections.