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  2. Upper motor neuron lesion - Wikipedia

    en.wikipedia.org/wiki/Upper_motor_neuron_lesion

    Conversely, a lower motor neuron lesion affects nerve fibers traveling from the anterior horn of the spinal cord or the cranial motor nuclei to the relevant muscle(s). [ 1 ] Upper motor neuron lesions occur in the brain or the spinal cord as the result of stroke , multiple sclerosis , traumatic brain injury , cerebral palsy , atypical ...

  3. D1–D2 dopamine receptor heteromer - Wikipedia

    en.wikipedia.org/wiki/D1–D2_dopamine_receptor...

    D 1 and D 2 receptors interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no involvement of transmembrane parts. The intracellular loop 3 of the D 2 receptor contains two adjacent arginine residues, while the carboxyl tail of the D 1 receptor possesses two adjacent glutamic acid residues.

  4. Brunnstrom Approach - Wikipedia

    en.wikipedia.org/wiki/Brunnstrom_Approach

    It was developed by the Swedish physical therapist Signe Brunnström, and emphasises the synergic pattern of movement which develops during recovery. This approach encourages development of flexor and extensor synergies during early recovery, with the intention that synergic activation of muscles will, with training, transition into voluntary ...

  5. Medium spiny neuron - Wikipedia

    en.wikipedia.org/wiki/Medium_spiny_neuron

    Medium spiny neurons have two primary phenotypes (characteristic types): D1-type MSNs of the direct pathway and D2-type MSNs of the indirect pathway. [2] [3] [4] Most striatal MSNs contain only D1-type or D2-type dopamine receptors, but a subpopulation of MSNs exhibit both phenotypes. [2] [3] [4]

  6. Upper motor neuron syndrome - Wikipedia

    en.wikipedia.org/wiki/Upper_motor_neuron_syndrome

    The saying refers to lower motor neuron symptoms in the upper extremity (arm) and upper motor neurons symptoms in the lower extremity (leg). Health professionals' understanding of impairments in muscles after an upper motor neuron lesion has progressed considerably in recent decades. However, a diagnosis of "spasticity" is still often used ...

  7. Upper motor neuron - Wikipedia

    en.wikipedia.org/wiki/Upper_motor_neuron

    Upper motor neurons (UMNs) is a term introduced by William Gowers in 1886. They are found in the cerebral cortex and brainstem and carry information down to activate interneurons and lower motor neurons, which in turn directly signal muscles to contract or relax. UMNs represent the major origin point for voluntary somatic movement.

  8. Pyramidal signs - Wikipedia

    en.wikipedia.org/wiki/Pyramidal_signs

    Pyramidal signs indicate that the pyramidal tract is affected at some point in its course. Pyramidal tract dysfunction can lead to various clinical presentations such as spasticity, weakness, slowing of rapid alternating movements, hyperreflexia, and a positive Babinski sign.

  9. Parkinsonian gait - Wikipedia

    en.wikipedia.org/wiki/Parkinsonian_gait

    Parkinsonian gait (or festinating gait, from Latin festinare [to hurry]) is the type of gait exhibited by patients with Parkinson's disease (PD). [2] It is often described by people with Parkinson's as feeling like being stuck in place, when initiating a step or turning, and can increase the risk of falling. [3]