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The average number of new cases of PKU varies in different human populations. United States Caucasians are affected at a rate of 1 in 10,000. [ 59 ] Turkey has the highest documented rate in the world, with 1 in 2,600 births, while countries such as Finland and Japan have extremely low rates with fewer than one case of PKU in 100,000 births.
Post-acute infection syndromes (PAISs) or post-infectious syndromes are medical conditions characterized by symptoms attributed to a prior infection. While it is commonly assumed that people either recover or die from infections, long-term symptoms—or sequelae—are a possible outcome as well. [1]
Skin temperature is the temperature of the outermost surface of the body. Normal human skin temperature on the trunk of the body varies between 33.5 and 36.9 °C (92.3 and 98.4 °F), though the skin's temperature is lower over protruding parts, like the nose, and higher over muscles and active organs. [ 1 ]
Normal human body temperature varies slightly from person to person and by the time of day. Consequently, each type of measurement has a range of normal temperatures. The range for normal human body temperatures, taken orally, is 36.8 ± 0.5 °C (98.2 ± 0.9 °F). [12]
Phenylketonuria (PKU)-like symptoms, including more pronounced developmental defects, skin irritation, and vomiting, may appear when phenylalanine levels are near 20 mg/dL (1200 mol/L). [1] Hyperphenylalaninemia is a recessive hereditary metabolic disorder that is caused by the body's failure to convert phenylalanine to tyrosine as a result of ...
Hyperpyrexia is an extreme elevation of body temperature which, depending upon the source, is classified as a core body temperature greater than or equal to 40 or 41 °C (104 or 106 °F); the range of hyperpyrexia includes cases considered severe (≥ 40 °C) and extreme (≥ 42 °C).
Adjusting the human body temperature downward has been used therapeutically, in particular, as a method of stabilizing a body following trauma. It has been suggested that adjusting the adenosine A1 receptor of the hypothalamus may allow humans to enter a hibernation -like state of reduced body temperature, which could be useful for applications ...
Most have a normal body temperature set point that falls within the range of 36.0 to 37.5 °C (96.8 to 99.5 °F). [13] The main reason for checking body temperature is to solicit any signs of systemic infection or inflammation in the presence of a fever. Fever is considered temperature of 37.8 °C (100.0 °F) or above. [13]