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Evaluation of a patient with eosinophilia should seek to identify the underlying cause and assess the patient for associated organ involvement. This topic presents our approach to evaluation of unexplained peripheral blood eosinophilia.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction characterized by an extensive skin rash in association with visceral organ involvement, lymphadenopathy, eosinophilia, and atypical lymphocytosis.
A high index of suspicion is often necessary to expeditiously establish the diagnosis. This topic will review the epidemiology, clinical manifestations, diagnosis, and management of drug-induced liver injury (DILI).
The recognition of drug fever is clinically important. Failure to recognize the etiologic relationship between a drug and fever often has undesired consequences including extra testing, unnecessary therapy, and longer hospital stays. This topic reviews the clinical approach to drug fever.
Exanthematous (maculopapular) drug eruption, also called morbilliform (measles-like) drug-induced exanthem, is the most common drug hypersensitivity reaction [1,2]. It is characterized by a disseminated, and occasionally generalized, symmetric eruption of erythematous macules and/or papules (picture 1A-B) that occur approximately one to two ...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction characterized by an extensive skin rash in association with visceral organ involvement, lymphadenopathy, eosinophilia, and atypical lymphocytosis.
This topic will review causes, pathogenesis, clinical manifestations, diagnosis, and approach to management of drug-induced lupus. The clinical manifestations, diagnosis, and treatment of idiopathic SLE in adults and in children are presented elsewhere.
Less frequently, AIN may present as a component of DRESS (ie, drug reaction with eosinophilia and systemic symptoms) syndrome or be secondary to infection, sarcoidosis, or checkpoint inhibitor immunotherapy.
This topic will discuss the pathogenesis, clinical manifestations, diagnosis, and treatment of lichenoid drug eruptions. Lichen planus and other types of cutaneous adverse reactions to drugs are discussed separately.
Evaluation of a patient with eosinophilia should seek to identify the underlying cause and assess the patient for associated organ involvement. This topic presents our approach to evaluation of unexplained peripheral blood eosinophilia.