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Side effects of spironolactone which may be indicative of hyperkalemia and if persistent could justify serum potassium testing include nausea, fatigue, and particularly muscle weakness. [63] Notably, non-use of routine potassium monitoring with spironolactone in young women would reduce costs associated with its use. [63]
Spironolactone has shown no significant effect on levels of testosterone, estradiol, luteinizing hormone, and follicle-stimulating hormone in men. [ 146 ] [ 78 ] No or only small changes in cortisol levels have been observed in clinical studies with spironolactone.
Spirolactones are a class of functional group in organic chemistry featuring a cyclic ester attached spiro to another ring system. The name is also used to refer to a class of synthetic steroids, called steroid-17α-spirolactones, 17α-spirolactosteroids, or simply 17α-spirolactones, which feature their spirolactone group at the C17α position.
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
Endocrine-disrupting chemicals affect hormones, which are chemicals that play the important role of carrying messages throughout your body to coordinate different functions in organs, skin ...
Hormones can be helpful heroes, supporting the immune system and a healthy sleep-wake schedule. But they can also be culprits of frustrating body issues, like excess weight that won’t come off ...
On the other hand, most [bio]identical hormone replacement therapy is absorbed across the skin, [and thus] avoids being metabolized in the liver, and tends to have less of a platelet aggregation ...
The antihypertensive actions of some diuretics (thiazides and loop diuretics in particular) are independent of their diuretic effect. [ 1 ] [ 2 ] That is, the reduction in blood pressure is not due to decreased blood volume resulting from increased urine production , but occurs through other mechanisms and at lower doses than that required to ...
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