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2. Spironolactone - Wikipedia

   en.wikipedia.org/wiki/Spironolactone

   Although spironolactone poses an important risk of hyperkalemia in the elderly, in those with kidney or cardiovascular disease, and/or in those taking medications or supplements which increase circulating potassium levels, a large retrospective study found that the rate of hyperkalemia in young women without such characteristics who had been ...

3. Everything I Wish I Knew About Taking Spironolactone for Acne

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   Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Skip to main content. Sign in. Mail. 24/7 Help. For premium support please call: 800-290-4726 ...

4. Why are dermatologists prescribing women a blood pressure ...

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   One phase 3 clinical trial, published in The BMJ last year, followed 400 women taking either spironolactone or a placebo for 24 weeks. Side effects were slightly more common in women who got the ...

5. What I Wish I Knew Before Taking Spironolactone for My ...

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6. Acne - Wikipedia

   en.wikipedia.org/wiki/Acne

   [1] [37] [125] Spironolactone is an aldosterone antagonist and is a useful acne treatment due to its ability to additionally block the androgen receptor at higher doses. [37] [105] Alone or in combination with a birth control pill, spironolactone has shown a 33 to 85% reduction in acne lesions in women. [116]

7. Mineralocorticoid receptor antagonist - Wikipedia

   en.wikipedia.org/wiki/Mineralocorticoid_receptor...

   However, spironolactone is metabolized to three active metabolites, which give it prolonged activity (13.8 – 16. 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease therefore require close monitoring when taking the drug. Spironolactone is also eliminated through feces (35-41%

8. 7α-Thiospironolactone - Wikipedia

   en.wikipedia.org/wiki/7α-thiospironolactone

   Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6]

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