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An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
For example, the ISMP "do not crush" list [27] can be entered into the system so that warning stickers can be printed at the point of dispensing, to be stuck on the pill bottle. Pharmaceutical companies that do not supply a range of half-dose and quarter-dose versions of time-release tablets can make it difficult for patients to be slowly ...
Crushing slow-releasing tablets or enteric coated medicines may also reduce absorption of the medicines. [12] Mixing medications with food or drink may also affect the metabolism of the drug. For example, grapefruit juice changes the bioavailability of many medicines by decreasing the rate of elimination. [13]
PPI exist in the forms of oral enteric coated tablets or enteric granules capped within capsules. To ensure the effectiveness of the medication, patients should swallow the whole tablet. [ 62 ] They should not chew or cut the tablets, nor open the capsule and grind the granules. [ 62 ]
Special coatings (for example with pearlescent effects) can enhance brand recognition. If the active ingredient of a tablet is sensitive to acid, or is irritant to the stomach lining, an enteric coating can be used, which is resistant to stomach acid, and dissolves in the less acidic area
Buccal tablets offer many advantages over other solid dosage forms also intended for oral administration (e.g. enteric-coated tablets, chewable tablets, and capsules). Buccal tablets can be considered in patients who experience difficulty in swallowing, since these tablets are absorbed into the blood stream between the gum and cheek.
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Coatings on a tablet or pellet may act as barriers to reducing the dissolution rate. Coatings may also be used to control where dissolution takes place. For example, enteric coatings only dissolve in the basic environment of the intestines. Drugs held in solution do not need to be dissolved before being absorbed.