Search results
Results from the WOW.Com Content Network
An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
Some medicines are incompatible with various minerals including calcium, iron, magnesium, and zinc, all of which may reduce absorption. [11] Crushing slow-releasing tablets or enteric coated medicines may also reduce absorption of the medicines. [12] Mixing medications with food or drink may also affect the metabolism of the drug.
Methenamine mandelate is provided as an enteric coated tablet and is taken four times daily, whereas methenamine hippurate is available only in non-coated tablet form and is taken twice daily. [8] [14] [9] [4] Non-coated methenamine tablets can have a chemical taste described as sweet, sour, and/or metallic. [14] [37] [38]
The fastest route of absorption is inhalation. [5] Absorption is a primary focus in drug development and medicinal chemistry, since a drug must be absorbed before any medicinal effects can take place. Moreover, the drug's pharmacokinetic profile can be easily and significantly changed by adjusting factors that affect absorption.
Enteric coated tablets are designed to dissolve in the intestine, not the stomach, because the drug present in the tablet causes irritation in the stomach. Administering medication rectally. The rectal route is an effective route of administration for many medications, especially those used at the end of life.
Variations on a common tablet design, which can be distinguished by both colour and shape. A caplet is a smooth, coated, oval-shaped medicinal tablet in the general shape of a capsule. Many caplets have an indentation running down the middle, so they may be split in half more easily. [5]
Multi-purpose tablets—Soluble tablets for either oral or sublingual (or buccal) administration, often also suitable for preparation of injections, Hydrostat (hydromorphone) and a number of brands of morphine tablets and cubes. Sublingual drops—a concentrated solution to be dropped under the tongue, as with some nicocodeine cough preparations,
Buccal tablets offer many advantages over other solid dosage forms also intended for oral administration (e.g. enteric-coated tablets, chewable tablets, and capsules). Buccal tablets can be considered in patients who experience difficulty in swallowing, since these tablets are absorbed into the blood stream between the gum and cheek.