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The cause of tetralogy of Fallot is typically not known. [5] Risk factors include a mother who uses alcohol , has diabetes , is over the age of 40, or gets rubella during pregnancy . [ 5 ] : 62 It may also be associated with Down syndrome and other chromosomal defects that cause congenital heart defects.
Tetralogy of Fallot is actually the most common cause of cyanotic congenital heart defects, accounting for about 50-70%, as well as about 10% of all congenital heart defects in general. Now, it’s not quite clear why some babies develop TOF but it is associated with chromosome 22 deletions and DiGeorge syndrome.
The most common cause of right-to-left shunt is the Tetralogy of Fallot, a congenital cardiac anomaly characterized by four co-existing heart defects. Pulmonary stenosis (narrowing of the pulmonary valve and outflow tract, obstructing blood flow from the right ventricle to the pulmonary artery)
[3] [12] In about 6 to 19 per 1,000 they cause a moderate to severe degree of problems. [12] Congenital heart defects are the leading cause of birth defect-related deaths: [3] in 2015, they resulted in 303,300 deaths, down from 366,000 deaths in 1990. [13] [14] The cause of a congenital heart defect is often unknown. [4]
The results of the blood test are then combined with the NT ultrasound measurements, maternal age, and gestational age of the fetus to yield a risk score for Down syndrome, trisomy 18, and trisomy 13. First Trimester Combined Test has a sensitivity (i.e. detection rate for abnormalities) of 82–87% and a false-positive rate of around 5%. [73] [74]
English: What is Tetralogy of Fallot? Tetralogy of Fallot (TOF) is a congenital heart condition characterized by four heart abnormalities—stenosis in the right ventricular outflow tract, right ventricular hypertrophy, ventricular septal defect, and aortic override of septal defect. Together, these can cause cyanosis in the newborn.
The most common heart defects seen with VACTERL association are ventricular septal defect (VSD), atrial septal defects and tetralogy of Fallot. Less common defects are truncus arteriosus and transposition of the great arteries. It is subsequently thought that cardiac defects should be considered an extension of VACTERL. [4]
The Blalock–Thomas–Taussig shunt (BTT shunt), [1] previously known as the Blalock–Taussig Shunt (BT shunt), [2] is a surgical procedure used to increase blood flow to the lungs in some forms of congenital heart disease [3] such as pulmonary atresia and tetralogy of Fallot, which are common causes of blue baby syndrome. [3]