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The middle cerebellar peduncle is the largest of the three cerebellar peduncles. It connects the pons and cerebellum.It consists almost entirely of fibers passing from the pons to the cerebellum (fibrocerebellar fibers); the fibers arise from the pontine nuclei and decussate within the pons before entering the peduncle [1] to end in the contralateral cerebellar hemisphere.
As patients with FXTAS can have distinct brain scans from other movement disorders, a scan showing white matter lesions of the middle cerebellar peduncle is a major finding that can be attributed to FXTAS. Overall or generalized brain tissue atrophy and cerebral white matter lesions can also be minor indicators for a diagnosis. [9]
Benedikt syndrome is caused by a lesion (infarction, hemorrhage, tumor, or tuberculosis) in the tegmentum of the midbrain and cerebellum. Specifically, the median zone is impaired. It can result from occlusion of the posterior cerebral artery [1] or paramedian penetrating branches of the basilar artery. [2]
Posterior cerebral artery is #6, and midbrain is behind it. Claude's syndrome is caused by midbrain infarction as a result of occlusion of a branch of the posterior cerebral artery. [2] This lesion is usually a unilateral infarction of the red nucleus and cerebellar peduncle, affecting several structures in the midbrain including:
Weber's syndrome, also known as midbrain stroke syndrome or superior alternating hemiplegia, is a form of stroke that affects the medial portion of the midbrain. It involves oculomotor fascicles in the interpeduncular cisterns and cerebral peduncle so it characterizes the presence of an ipsilateral lower motor neuron type oculomotor nerve palsy and contralateral hemiparesis or hemiplegia.
Cerebellar stroke syndrome is a condition in which the circulation to the cerebellum is impaired due to a lesion of the superior cerebellar artery, anterior inferior cerebellar artery or the posterior inferior cerebellar artery. [1] Cardinal signs include vertigo, headache, vomiting, and ataxia. [2]
Cerebral infarction, also known as an ischemic stroke, is the pathologic process that results in an area of necrotic tissue in the brain (cerebral infarct). [1] In mid to high income countries, a stroke is the main reason for disability among people and the 2nd cause of death. [ 2 ]
The cerebellar peduncles are three paired bundles of fibres that connect the cerebellum to the brain stem. [1] Superior cerebellar peduncle is a paired structure of white matter that connects the cerebellum to the mid-brain. Middle cerebellar peduncles connect the cerebellum to the pons and are composed entirely of centripetal fibers.