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The company works in regenerative medicine, in which it owns several extracellular matrix patents. [1] ACell develops, manufactures and markets products for medical and veterinary applications. [2] The company was founded by Alan R. Spievack, a former associate professor at Harvard Medical School and is currently run by Patrick A. McBrayer. [3] [4]
The animal extracellular matrix includes the interstitial matrix and the basement membrane. [7] Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. [8]
In biology, matrix (pl.: matrices) is the material (or tissue) in between a eukaryotic organism's cells. The structure of connective tissues is an extracellular matrix. Fingernails and toenails grow from matrices. It is found in various connective tissues. It serves as a jelly-like structure instead of cytoplasm in connective tissue.
The major components of Cultrex BME include laminin, collagen, entactin/nidogen, and heparin sulfate proteoglycans.These components are found in the basement membrane extracellular matrix that forms an interface between stromal tissue and adjacent endothelial, epithelial, muscle, or neuronal cells.
Ovine forestomach matrix (OFM) (marketed as AROA ECM) is a layer of decellularized extracellular matrix (ECM) biomaterial isolated from the propria submucosa of the rumen of sheep. [ 1 ] [ 2 ] OFM is used in tissue engineering and as a tissue scaffold for wound healing and surgical applications [ 3 ] [ 4 ]
EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene. [4] [5] [6]A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during ...
The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. [1] [2] The basement membrane sits between epithelial tissues including mesothelium and endothelium, and the underlying connective tissue. [3] [4]
A matricellular protein is a dynamically expressed non-structural protein that is present in the extracellular matrix (ECM). [1] [2] Rather than serving as stable structural elements in the ECM, these proteins are rapidly turned over and have regulatory roles. They characteristically contain binding sites for ECM structural proteins and cell ...