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PSA grades millions of cards per year, many worth six or seven figures. Without insurance, collectors face significant financial risk if their cards are lost or damaged, despite PSA’s public assurances of security. The first significantly controversial card grade was in fact the first card ever graded by PSA. This was the T206 Honus Wagner ...
The Gleason grading system is used to help evaluate the prognosis of men with prostate cancer using samples from a prostate biopsy. Together with other parameters, it is incorporated into a strategy of prostate cancer staging which predicts prognosis and helps guide therapy. A Gleason score is given to prostate cancer based upon its microscopic ...
While the general arguments in the paper recommending reforms in scientific research methodology were well-received, Ionnidis received criticism for the validity of his model and his claim that the majority of scientific findings are false. Responses to the paper suggest lower false positive and false negative rates than what Ionnidis puts forth.
Prostate cancer is a major topic of ongoing research. From 2016 to 2020, over $1.26 billion was invested in prostate cancer research, representing around 5% of global cancer research funds. [122] This places prostate cancer 10th among 18 common cancer types in funding per cancer death, and 9th in funding per disability-adjusted life year lost ...
Grading in cancer is distinguished from staging, which is a measure of the extent to which the cancer has spread. Pathology grading systems classify the microscopic cell appearance abnormality and deviations in their rate of growth with the goal of predicting developments at tissue level (see also the 4 major histological changes in dysplasia).
Collectors Universe Inc. is an American company formed in 1986, now based in Santa Ana, California, which provides third-party authentication and grading services to collectors, retail buyers and sellers of collectibles. Its authentication services focus on coins, trading cards, sports memorabilia, and autographs.
The Common Terminology Criteria for Adverse Events (CTCAE), [1] formerly called the Common Toxicity Criteria (CTC or NCI-CTC), are a set of criteria for the standardized classification of adverse events of drugs and treatment used in cancer therapy. The CTCAE system is a product of the US National Cancer Institute (NCI).
PSA based screening and treatment of prostate cancer at a localized stage can prevent prostate cancer death for some men. [ 7 ] [ 10 ] However, if curative intervention is the downstream consequence of every screen detected prostate cancer, a large proportion of men will undergo unnecessary treatment and experience functional declines in ...