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Febrile neutropenia or neutropenic fever is a defined as a single oral temperature value of ≥ 38.3 C (101 F) or a temperature ≥ 38 C (100.4 F) for ≥ 1 hour, with an absolute neutrophil count (ANC) < 1500 cell/microliter. [1]
Furthermore, emerging research suggests neutropenia without an identifiable etiology (idiopathic neutropenia) may be the result of a low-grade, chronic inflammatory process with an abnormal excessive production of myelosuppressive cytokines in a study conducted in the island of Crete. [33] Neutropenia fever can complicate the treatment of cancers.
Neutropenia generally develops in the second week. During this period, many clinicians recommend pegfilgrastim or prophylactic use of ciprofloxacin . [1] If a fever develops in the neutropenic period, urgent medical assessment is required for neutropenic sepsis , as infections in patients with low neutrophil counts may progress rapidly.
The quality of life and survival greatly improves with G-CSF treatment, which is practiced since the late 1980s. [21] Unlike severe congenital neutropenia, individuals with cyclic neutropenia have a better response to G-CSF and do not have a risk of developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
Fever of unknown origin (FUO) refers to a condition in which the patient has an elevated temperature for which no cause can be found despite investigations by one or more qualified physicians. [ 1 ] [ 2 ] [ 3 ] If the cause is found, it is usually a diagnosis of exclusion , eliminating all possibilities until only the correct explanation remains.
“The MRD data further underscores the benefits of treatment with CARVYKTI,” said Yi Lin, M.D., Ph.D., hematologist and oncologist at Mayo Clinic, Rochester, MN. “These new findings support CARVYKTI as a transformative therapeutic option, leading to improved progression-free survival, overall survival, and now minimal residual disease ...
Severe congenital neutropenia (SCN), also often known as Kostmann syndrome or disease, is a group of rare disorders that affect myelopoiesis, causing a congenital form of neutropenia, usually without other physical malformations.
Fever of at least 39 °C, OR a rise in temperature of at least 2 °C from pre-transfusion values AND/OR other symptoms or signs, including chills (), painful muscles (), or nausea that are severe enough that the transfusion is stopped AND requires immediate medical treatment, admission to hospital, or lengthens the duration of hospital admission.