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Foamy macrophages are also found in diseases caused by pathogens that persist in the body, such as Chlamydia, Toxoplasma, or Mycobacterium tuberculosis. In tuberculosis (TB), bacterial lipids disable macrophages from pumping out excess LDL, causing them to turn into foam cells around the TB granulomas in the lung. The cholesterol forms a rich ...
A signet ring-like foamy macrophage, which may mimic a cancer cell, but the texture of the nucleus is similar to that of a normal macrophage. High magnification micrograph showing signet ring cells , with clear cytoplasm, in metastatic breast carcinoma .
Duct ectasia of the breast, mammary duct ectasia or plasma cell mastitis is a condition that occurs when a milk duct beneath the nipple widens, the duct walls thicken, and the duct fills with fluid. This is the most common cause of greenish discharge. [1] Mammary duct ectasia can mimic breast cancer. It is a disorder of peri- or post-menopausal ...
The foam cells of monocyte/macrophage origin are positive for KP1, HAM56, CD11b and CD68 as pointed out by Nakashiro et al. in xanthogranulomatous cholecystitis). [20] Many T lymphocytes were identified by these authors positive to CD4 and CD8. Macrophages and T lymphocytes demonstrated a marked expression of HLA-DR antigen.
Giant cells are also known to develop when infections are present. They were first observed as early as the middle of the last century, but it is not fully understood why these reactions occur. In the process of giant cell formation, monocytes or macrophages fuse together, which could cause multiple problems for the immune system. [citation needed]
It consists of aggregates of foam cells, which are lipoprotein-loaded macrophages, [1] located in the intima, the innermost layer of the artery, beneath the endothelial cells that layer the lumina through which blood flows. Fatty streaks may also include T cells, aggregated platelets, and smooth muscle cells.
At the microscopic scale foamy macrophages and giant cells are seen in the airways, and the inflammatory response is visible in the parenchyma. [citation needed] On CT, lipoid pneumonia appears as a "crazy paving" pattern, characterized by ground glass opacities with interspersed interlobular septal thickening. [8]
Tissue encapsulation of an implant is an example, as is inflammation around a splinter. [3] Foreign body granuloma formation consists of protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis. It has also been proposed that the mechanical property of the interface between an ...