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The subcallosal cingulate gyrus CG25 which consists of BA25 as well as parts of BA24 and BA32 has been implicated as playing an important role in major depression and has been the target of deep brain stimulation to treat the disorder. [6] One study found that BA25 is metabolically overactive in treatment-resistant depression. [7]
The adjacent subcallosal cingulate gyrus has been implicated in major depression and research indicates that deep-brain stimulation of the region could act to alleviate depressive symptoms. [38] Although people with depression had smaller subgenual ACCs, [39] their ACCs were more active when adjusted for size.
Deep brain stimulation ... Beginning in the 1950s, treatment has been attempted in the subcallosal cingulate region [51] and the ventral capsule/ventral striatum ...
The cingulate cortex is a part of the brain situated in the medial aspect of the cerebral cortex. The cingulate cortex includes the entire cingulate gyrus, which lies immediately above the corpus callosum, and the continuation of this in the cingulate sulcus. The cingulate cortex is usually considered part of the limbic lobe.
The subcallosal area (parolfactory area of Broca) is a small triangular field on the medial surface of the hemisphere in front of the subcallosal gyrus, from which it is separated by the posterior parolfactory sulcus; it is continuous below with the olfactory trigone, and above and in front with the cingulate gyrus; it is limited anteriorly by the anterior parolfactory sulcus.
The term is ambiguous, with some authors [who?] including the paraterminal gyrus, the subcallosal area, the cingulate gyrus, the parahippocampal gyrus, the dentate gyrus, the hippocampus and the subiculum; [1] while the Terminologia Anatomica includes the cingulate sulcus, the cingulate gyrus, the isthmus of cingulate gyrus, the fasciolar gyrus ...
Mayberg is known in particular for her work delineating abnormal brain function in patients with major depression using functional neuroimaging. [1] [2] This work led to the first pilot study of deep brain stimulation (DBS), a reversible method of selective modulation of a specific brain circuit, for patients with treatment-resistant depression ...
It is located beneath the cingulate gyrus within the medial surface of the brain therefore encircling the entire brain. There are two primary parts of the cingulate cortex: the posterior cingulate cortex and the anterior cingulate cortex. The anterior is linked to emotion, especially apathy and depression. Here function and structure changes ...
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