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  2. Opioid receptor - Wikipedia

    en.wikipedia.org/wiki/Opioid_receptor

    An animated view of the human κ-opioid receptor in complex with the antagonist JDTic. Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. [1] [2] [3] The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostatin ...

  3. μ-opioid receptor - Wikipedia

    en.wikipedia.org/wiki/Μ-opioid_receptor

    Activation of the μ-opioid receptor by an agonist such as morphine causes analgesia, sedation, slightly reduced blood pressure, itching, nausea, euphoria, decreased respiration, miosis (constricted pupils), and decreased bowel motility often leading to constipation. Some of these effects, such as analgesia, sedation, euphoria, itching and ...

  4. κ-opioid receptor - Wikipedia

    en.wikipedia.org/wiki/Κ-opioid_receptor

    The κ-opioid receptor or kappa opioid receptor, abbreviated KOR or KOP for its ligand ketazocine, is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene. The KOR is coupled to the G protein G i /G 0 and is one of four related receptors that bind opioid -like compounds in the brain and are responsible for mediating the ...

  5. Agonist-antagonist - Wikipedia

    en.wikipedia.org/wiki/Agonist-antagonist

    The best known agonist-antagonists are opioids. Examples of such opioids are: pentazocine, agonist at the kappa (κ) and sigma (σ) and has a weak antagonist action at the mu opioid receptor (μ) [4] butorphanol, partial agonist at μ- and a pure agonist at κ-opioid receptor and antagonist activity at the delta opioid receptor (δ) [5]

  6. Agonist - Wikipedia

    en.wikipedia.org/wiki/Agonist

    An irreversible agonist is a type of agonist that binds permanently to a receptor through the formation of covalent bonds. [2] [3] A biased agonist is an agent that binds to a receptor without affecting the same signal transduction pathway. Oliceridine is a μ-opioid receptor agonist that has been described to be functionally selective towards ...

  7. Opioid antagonist - Wikipedia

    en.wikipedia.org/wiki/Opioid_antagonist

    An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors. Fentanyl . 2 mg (white powder to the right) is a lethal dose in most people. [ 1 ]

  8. Opioid - Wikipedia

    en.wikipedia.org/wiki/Opioid

    This appears to largely be a result of actions of opioid drugs at targets other than the three classic opioid receptors, including the nociceptin receptor, sigma receptor and Toll-like receptor 4, and can be counteracted in animal models by antagonists at these targets such as J-113,397, BD-1047 or (+)-naloxone respectively. [134]

  9. δ-opioid receptor - Wikipedia

    en.wikipedia.org/wiki/Δ-opioid_receptor

    The endogenous system of opioid receptors is well known for its analgesic potential; however, the exact role of δ-opioid receptor activation in pain modulation is largely up for debate. This also depends on the model at hand since receptor activity is known to change from species to species.

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