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Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [10] cSCC typically presents as a hard lump with a scaly surface, though it may also present as an ulcer. [1]
small-cell keratinizing squamous-cell carcinoma (code 8073/3) spindle-cell squamous-cell carcinoma (code 8074/3) It is also known as spindle-cell carcinoma, [23] and is a subtype characterized by spindle-shaped atypical cells. [24] adenoid/pseudoglandular squamous-cell carcinoma (code 8075/3) intraepidermal squamous-cell carcinoma (code 8081/3)
Dermatoscopy may be useful in diagnosing basal cell carcinoma in addition to skin inspection. [42] There is insufficient evidence that optical coherence tomography (OCT) is useful in diagnosing melanoma or squamous cell carcinoma. OCT may have a role in diagnosing basal cell carcinoma but more data is needed to support this. [43]
All squamous cell carcinoma lesions are thought to begin via the repeated, uncontrolled division of cancer stem cells of epithelial lineage or characteristics. Accumulation of these cancer cells causes a microscopic focus of abnormal cells that are, at least initially, locally confined within the specific tissue in which the progenitor cell resided.
Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that covers the vulva. VIN is an intraepithelial neoplasia , and can disappear without treatment. VINs are benign but if the changes become more severe, there is a chance of cancer developing after many years, and so it is referred to as a ...
Squamous-cell carcinoma of the lung is closely correlated with a history of tobacco smoking, more so than most other types of lung cancer.According to the Nurses' Health Study, the relative risk of SCC is approximately 5.5, both among those with a previous duration of smoking of 1 to 20 years, and those with 20 to 30 years, compared to never-smokers. [2]
A survey of 23 countries between 1983 and 2002 showed an increase in oropharyngeal squamous cell carcinoma that was particularly noticeable in young men in economically developed countries. [220] [12] In the United Kingdom the incidence of oral and oropharyngeal cancer in men rose 51%, from 7/100,000 to 11/100,000 between 1989 and 2006. [233]
Anal cancer is typically a squamous cell carcinoma. [3] Other types include adenocarcinoma, small cell carcinoma, and melanoma. [3] Diagnosis is suspected based on physical examination and confirmed by tissue biopsy. [1] Prevention includes avoiding risk factors and HPV vaccination. [6]
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