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The vaccine contains 50 mcg of purified polysaccharide for each of the serogroups (A, C, Y, and W135) in a lyophilized form. The active pharmaceutical ingredient of the C, Y, and W-135 serogroups is sialic acid. Phosphate is an API for serogroup A. Lactose is used as a stabilizer. As a precautionary measure, mercury is not used in the vaccine ...
By two years of age, U.S. children receive as many as 24 vaccine injections, and might receive up to five shots during one visit to the doctor. [4] The use of combination vaccine products means that, as of 2013 [update] , the United Kingdom's immunization program consists of nine injections by the age of two, rather than 22 if vaccination for ...
Leptospirosis is a blood infection caused by the bacterium Leptospira [8] that can infect humans, dogs, rodents and many other wild and domesticated animals. [8] Signs and symptoms can range from none to mild ( headaches , muscle pains , and fevers ) to severe ( bleeding in the lungs or meningitis ). [ 5 ]
Leptospirosis is treated with the antibiotics doxycycline and penicillin. [28] There are more than 200 diverse pathogenic Leptospira serovars, making it challenging to develop an effective vaccine. [31] However, vaccines for the serovars known as Hardjo, Pomona, Canicola, Grippotyphosa and icterohaemorrhagiae have been developed.
L. interrogans can also obtain iron from heme, which is bound to most of the iron in the human body. The HbpA hemin-binding protein, which may be involved in the uptake of hemin , has been identified on the surface of L. interrogans [ 35 ] Although other pathogenic species of Leptospira and L. biflexa lack HbpA, yet another hemin-binding ...
An increasing number of children are undervaccinated, of whom an estimated 13% or more are believed to be so because of parental choice. [15] One survey, published in Vaccine, found that 9.4% of parents in King County, Washington used an alternative vaccine schedule, [1] while another survey found that more than 1 out of 10 parents of children aged between 6 months and 6 years used an ...
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Until the 1880s vaccine/vaccination referred only to smallpox, but Louis Pasteur developed immunization methods for chicken cholera and anthrax in animals and for human rabies, and suggested that the terms vaccine/vaccination should be extended to cover the new procedures. This can cause confusion if care is not taken to specify which vaccine ...