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Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. [4] This includes ventricular tachycardia, ventricular fibrillation, and wide complex tachycardia, atrial fibrillation, and paroxysmal supraventricular tachycardia. [4]
Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]
Persistent AIT that does not respond to treatment regardless of the subtype will likely have to consider alternatives such as plasmapheresis or surgery. [7] [8] Monitoring is highly recommended for patients taking amiodarone, and thyroid function should be regularly evaluated during treatment and for at least one year following drug cessation. [2]
The Jod-Basedow effect (also Jod-Basedow syndrome and Jod-Basedow phenomenon) is hyperthyroidism following administration of iodine or iodide, [1] either as a dietary supplement, for iodinated contrast medical imaging, or as a medication (mainly amiodarone).
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When taken independently, erythromycin has been shown to cause both QT prolongation and TdP. Erythromycin works inhibiting the CYP3A protein. Patients who have low CYP3A activity and are also concurrently taking other medications such as disopyramide, which can lead to QT prolongation and TdP. Fluoroquinolones. Ciprofloxacin; Levofloxacin ...
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