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The Ferrier Lecture is a Royal Society lectureship given every three years "on a subject related to the advancement of natural knowledge on the structure and function of the nervous system". [1] It was created in 1928 to honour the memory of Sir David Ferrier , a neurologist who was the first British scientist to electronically stimulate the ...
PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). [1] PCR inhibition is the most common cause of amplification failure when sufficient copies of DNA are present. [2] PCR inhibitors usually affect PCR through interaction with DNA or interference with the DNA polymerase.
In his 50-year career, Ferrier published 180 papers, reviews and books, and gave 10 invited plenary lectures at international symposia. [15] His reviews were of particular benefit to the chemical community but perhaps of most value was the book "Monosaccharide Chemistry, [ 16 ] written with Dr Peter Collins in 1972 and majorly updated as ...
Sir David Ferrier FRS (13 January 1843 – 19 March 1928) was a pioneering Scottish neurologist and psychologist.Ferrier conducted experiments on the brains of animals such as monkeys and in 1881 became the first scientist to be prosecuted under the Cruelty to Animals Act, 1876 which had been enacted following a major public debate over vivisection.
Image illustrates DNA, RNA, and protein synthesis. The first two are nucleic acids. A nucleic acid inhibitor is a type of antibacterial that acts by inhibiting the production of nucleic acids. There are two major classes: DNA inhibitors and RNA inhibitors. [1] The antifungal flucytosine acts in a similar manner.
All genetic engineering processes involve the modification of DNA. Traditionally DNA was isolated from the cells of organisms. Later, genes came to be cloned from a DNA segment after the creation of a DNA library or artificially synthesised. Once isolated, additional genetic elements are added to the gene to allow it to be expressed in the host ...
Bayraktar and Kreutz [39] found that DNMT inhibitors, applied in the brain, prevented long-term memories from forming. DNMT3L contains DNA methyltransferase motifs and is required for establishing maternal genomic imprints, despite being catalytically inactive. DNMT3L is expressed during gametogenesis when genomic imprinting takes place.
ID proteins are key regulators of development where they function to prevent premature differentiation of stem cells. [7] By inhibiting the formation of E-protein dimers that promote differentiation, ID proteins can regulate the timing of differentiation of stem cells during development. [8]