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  2. Alendronic acid - Wikipedia

    en.wikipedia.org/wiki/Alendronic_acid

    Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [ 4 ] Use is often recommended together with vitamin D , calcium supplementation , and lifestyle changes.

  3. Bisphosphonate - Wikipedia

    en.wikipedia.org/wiki/Bisphosphonate

    Bisphosphonates are used to treat osteoporosis, osteitis deformans (Paget's disease of the bone), bone metastasis (with or without hypercalcemia), multiple myeloma, and other conditions involving fragile, breakable bone. In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate.

  4. Medication-related osteonecrosis of the jaw - Wikipedia

    en.wikipedia.org/wiki/Medication-related_osteo...

    Bisphosphonates are either administered orally or intravenously. They reduce bone resorption. [31] Mechanism of action: Bisphosphonate binds to the mineral component of the bone and inhibits enzymes (i.e. farnesyl-pyrophosphate synthase) responsible for bone formation, osteoclast recruitment and osteoclast function. [29] [31]

  5. Osteonecrosis of the jaw - Wikipedia

    en.wikipedia.org/wiki/Osteonecrosis_of_the_jaw

    Matrix metalloproteinase 2 may be a candidate gene for bisphosphonate-associated osteonecrosis of the jaw, since it is the only gene known to be associated with bone abnormalities and atrial fibrillation, both of which are side effects of bisphosphonates. [23]

  6. Paget's disease of bone - Wikipedia

    en.wikipedia.org/wiki/Paget's_disease_of_bone

    Etidronic acid and other bisphosphonates may be appropriate therapies for selected patients but are less commonly used. In one study it was reported that people experienced side effects when taking bisphosphonates for six months, however the quality of evidence was low. [27] None of these drugs should be used by people with severe kidney disease.

  7. Zoledronic acid - Wikipedia

    en.wikipedia.org/wiki/Zoledronic_acid

    Common side effects include fever, joint pain, high blood pressure, diarrhea, and feeling tired. [3] Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw. [3] Use during pregnancy may result in harm to the baby. [3] It is in the bisphosphonate family of medications. [3]

  8. Ibandronic acid - Wikipedia

    en.wikipedia.org/wiki/Ibandronic_acid

    Ibandronic acid is a bisphosphonate medication used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. [4] It may also be used to treat hypercalcemia (elevated blood calcium levels). It is typically formulated as its sodium salt ibandronate sodium. [medical citation needed]

  9. Alendronic acid/colecalciferol - Wikipedia

    en.wikipedia.org/wiki/Alendronic_acid/colecalciferol

    Alendronic acid/colecalciferol, sold under the brand name Fosamax Plus D among others, is a medication for the treatment of osteoporosis in men or in postmenopausal women. [ 3 ] [ 2 ] [ 4 ] [ 6 ] Alendronic acid/colecalciferol was approved for use in the United States and in the European Union in 2005.