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Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
PSA is a commonly used medicinal chemistry metric for the optimization of a drug's ability to permeate cells. Molecules with a polar surface area of greater than 140 angstroms squared (Å 2 ) tend to be poor at permeating cell membranes. [ 1 ]
A PSA of 4 nanograms per milliliter (ng/mL) is typically the cutoff that doctors use to recommend more testing, according to the American Cancer Society. If your levels are between 4 ng/mL and 10 ...
In physiology and medicine, the body surface area (BSA) is the measured or calculated surface area of a human body.For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass.
Volume Voxelator — A web-based tool to generate excluded surfaces. ASV freeware Analytical calculation of the volume and surface of the union of n spheres (Monte-Carlo calculation also provided). Vorlume Computing Surface Area and Volume of a Family of 3D Balls. GetArea Calculate solvent accessible surface area of proteins online.
PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. [16] A 2018 United States Preventive Services Task Force (USPSTF) recommendation adjusted the prior opposition to PSA screening, [17] suggesting shared decision-making regarding screening in healthy males 55 to 69 years of age. [17]
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{{Birth date and age}} – used on most biographical entries {{Birth date and age2}} – calculates age at a specified date {{Birth based on age as of date}} – used when a reference mentions the age of a person as of the date of the reference's publication {{Birth year and age}} {} {{Death date and age}} {{Death year and age}}
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