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This constitutes the so-called capsule of the space. Each lacuna is generally occupied by a single cell, but during the division of the cells, it may contain two, four, or eight cells. Lacunae are found between narrow sheets of calcified matrix that are known as lamellae (/ l ə ˈ m ɛ l i / lə-MEL-ee).
The cell undergoes a dramatic transformation from a polygonal shape to a cell that extends dendrites toward the mineralizing front, followed by dendrites that extend to either the vascular space or bone surface. [12] As the osteoblast transitions to an osteocyte, alkaline phosphatase is reduced, and casein kinase II is elevated, as is osteocalcin.
These cavities are actually artificial gaps formed from the shrinking of the cells during the staining and setting of the tissue for examination. The inter-territorial space between the isogenous cell groups contains relatively more collagen fibers, allowing it to maintain its shape while the actual cells shrink, creating the lacunae. This ...
The radiating processes of the osteocytes (called filopodia) project into these canals. These cytoplasmic processes are joined together by gap junctions. Osteocytes do not entirely fill up the canaliculi. The remaining space is known as the periosteocytic space, which is filled with periosteocytic fluid. This fluid contains substances too large ...
Osteocytes, the most common cell type within mature cortical bone, actively participate in the growth and maintenance of TCVs through the transfer of mitochondria to endothelial cells. Scanning electron microscopy images have revealed that osteocytes possess numerous dendritic processes with expanded, endfoot-like structures.
When referring to bone, or in this case cartilage, the originally undifferentiated mesenchymal stem cells lose their pluripotency, proliferate and crowd together in a dense aggregate of chondrogenic cells (cartilage) at the location of chondrification. These chondrogenic cells differentiate into so-called chondroblasts, which then synthesize ...
In the hollow within bones are many other cell types of the bone marrow. Components that are essential for osteoblast bone formation include mesenchymal stem cells (osteoblast precursor) and blood vessels that supply oxygen and nutrients for bone formation. Bone is a highly vascular tissue, and active formation of blood vessel cells, also from ...
Active transport is used to move most substances between the blood vessels and the osteocytes. [1] Haversian canals are contained within osteons, which are typically arranged along the long axis of the bone in parallel to the surface. The canals and the surrounding lamellae (8-15) form the functional unit, called a Haversian system, or osteon.