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The BMP-1, the predecessor to the BMP-2. Although the BMP-1 was a revolutionary design, its main armament, the 2A28 Grom and the 9S428 ATGM launcher capable of firing 9M14 Malyutka (NATO: AT-3A Sagger A) and 9M14M Malyutka-M (NATO: AT-3B Sagger B) ATGMs, quickly became obsolete.
Function. BMP-2 like other bone morphogenetic proteins, [6] plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine -cytokine receptor interaction. It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition.
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade. [3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II. [4]
BMPR2. Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signaling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and ...
In the 1970s, the plant was re-tooled for larger-scale military vehicle production. New power supplies were brought in, and the working area was increased by a factor of five. From 1983, the plant produced the BMP-2 model, and in 1987 began the manufacture of the BMP-3. [7] In 2007 the company's revenue was $231 million. Export share was 20%. [10]
The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include cancer ...
Muntra is a family modified Soviet BMP-2 armored personnel carrier intended to be used for Unmanned missions. Current variants are unarmed. Three variants exist: Muntra-S for surveillance, Muntra-M for mine clearing, and Muntra-N operating in nuclear or chemical contaminated zones. It has autonomous navigation through GPS waypoints with ...