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Their new text was first published in 1941 under the title The Pharmacological Basis of Therapeutics: A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Student. [1] Because the volume was twice as long as a typical textbook, Macmillan printed few copies, but demand for a readable, up-to-date pharmacological text ...
Cephalosporins are bactericidal and, like other β-lactam antibiotics, disrupt the synthesis of the peptidoglycan layer forming the bacterial cell wall. The peptidoglycan layer is important for cell wall structural integrity. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by penicillin-binding proteins (PBPs).
The CPhA is a nonprofit organization that advocates for pharmacists in Canada. An external Editorial Advisory Committee of Canadian physicians and pharmacists advises CPhA about the strategic direction of their publications including CPS. CPS is also available online by subscription at www.pharmacists.ca. Most of the drug monographs in CPS are ...
An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation [1] and inhibit thrombus formation. They are effective in the arterial circulation where classical Vitamin K antagonist anticoagulants have minimal ...
Drug class. A drug class is a group of medications and other compounds that have similar chemical structures, the same mechanism of action (i.e. binding to the same biological target), similar modes of action, and/or are used to treat the similar diseases. [1][2] The Food and Drug Administration (FDA) has worked on classifying and licensing new ...
Among the less invasive routes, the intranasal route has the highest bioavailability (45–50%) [7] [10] and oral – the lowest (16–20%). [7] [10] Sublingual and rectal bioavailabilities are intermediate at approximately 25–50%. [7] [11] [10] After absorption ketamine is rapidly distributed into the brain and other tissues. [90]
The list and notes are based on the 19th to 23rd edition of the main list. [4] [12] [14] [17] [27] Therapeutic alternatives with similar clinical performance are listed for some medicines and they may be considered for national essential medicines lists. [17] [18] The 9th Essential Medicines List for Children was updated in July 2023. [23] [28]
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose. It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1] The related terms therapeutic window or safety window ...