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The dermis is composed of three major types of cells: [3] fibroblasts, macrophages, and mast cells.. Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin (which provides elasticity), and extrafibrillar matrix, an extracellular gel-like substance primarily composed of glycosaminoglycans (most notably hyaluronan ...
As a result, mitochondria, within such cells, demonstrate a non-uniform distribution, and can be strategically localized in regions with the greatest energy needs. [25] In order to support the substantial metabolic demands of neurovascular coupling, astrocytic endfeet are loaded and packed with elongated and branched mitochondria. [26]
Typical mitochondrial network (green) in two human cells . Mitochondria (or related structures) are found in all eukaryotes (except the Oxymonad Monocercomonoides). [5] Although commonly depicted as bean-like structures they form a highly dynamic network in the majority of cells where they constantly undergo fission and fusion.
The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue guarding muscles, bones, ligaments and internal organs. Human skin is similar to most of the other mammals ' skin, and it is very similar to pig skin. Though nearly all human skin is covered ...
The stratum corneum (Latin for 'horny layer') is the outermost layer of the epidermis. Consisting of dead tissue, it protects underlying tissue from infection, dehydration, chemicals and mechanical stress. It is composed of 15–20 layers of flattened cells with no nuclei and cell organelles. Among its properties are mechanical shear, impact ...
The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. [ 1 ] The epidermis layer provides a barrier to infection from environmental pathogens [ 2 ] and regulates the amount of water released from the body into the atmosphere through transepidermal water loss. [ 3 ]
A Langerhans cell (LC) is a tissue-resident macrophage of the skin [2] once thought to be a resident dendritic cell. [3] These cells contain organelles called Birbeck granules. They are present in all layers of the epidermis and are most prominent in the stratum spinosum. [4] They also occur in the papillary dermis, particularly around blood ...
The stratum spinosum (or spinous layer/prickle cell layer) [1] is a layer of the epidermis found between the stratum granulosum and stratum basale. [2] This layer is composed of polyhedral keratinocytes. [3][4] These are joined with desmosomes. [3] Their spiny (Latin, spinosum) appearance is due to shrinking of the microfilaments between ...