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In this technique, one probe binds the reference which, in the case of HER-2/neu amplification detection, is CEN17 (the centromere of chromosome 17) while the other probe binds the target sequence which is HER-2/neu. [26] [27] DuoCISH combines both FISH and CISH in that it converts signals from FISH probes to chromogenic substrates.
Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. [10]
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
Date: 12 August 2019: Source: Own work, using following image: . Image source: Halilovic A, Verweij DI, Simons A, Stevens-Kroef MJPL, Vermeulen S, Elsink J (2019)."HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study.
HER2/neu status can be analyzed by fluorescent in-situ hybridization (FISH) assays. [39] Some commentators prefer this approach, claiming a higher correlation than receptor immunohistochemistry with response to trastuzumab , a targeted therapy, but guidelines permit either testing method.
HER2_FISH_with_a_yellow_signal.png (585 × 419 pixels, file size: 181 KB, MIME type: image/png) This is a file from the Wikimedia Commons . Information from its description page there is shown below.
Multiplexed error-robust fluorescence in situ hybridization [24] is a highly multiplexed version of smFISH. It uses combinatorial labeling, followed by imaging, and then error-resistant encoding [25] to capture a high number of RNA molecules and spatial localization within the cell. The capture of a large number of RNA molecules enables ...
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