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[43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
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Risperidone extended-release (Risperisphere) – dopamine D 2 and D 3 receptor antagonist, serotonin 5-HT 1B, 5-HT 2A, 5-HT 2C, and 5-HT 7 receptor antagonist or inverse agonist, α 1 - and α 2-adrenergic receptor antagonist, histamine H 1 receptor inverse agonist, and atypical antipsychotic [91]
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Ramelteon is an analogue of melatonin and is a selective agonist of the melatonin MT 1 and MT 2 receptors. [3] The half-life and duration of ramelteon are much longer than those of melatonin. [7] Ramelteon is not a benzodiazepine or Z-drug and does not interact with GABA receptors, instead having a distinct mechanism of action. [3] [8]
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