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The rapid plasma reagin test (RPR test or RPR titer) is a type of rapid diagnostic test that looks for non-specific antibodies in the blood of the patient that may indicate an infection by syphilis or related non-venereal treponematoses. It is one of several nontreponemal tests for syphilis (along with the Wassermann test and the VDRL test).
The rapid plasma reagin (RPR) test uses the same antigen as the VDRL, but in that test, it has been bound to several other molecules, including a carbon particle to allow visualization of the flocculation reaction without the need of a microscope. Many other medical conditions can produce false positive results, including some viruses ...
Treponemal antibody tests usually become positive two to five weeks after the initial infection [22] and remain positive for many years. [43] Neurosyphilis is diagnosed by finding high numbers of leukocytes (predominately lymphocytes) and high protein levels in the cerebrospinal fluid in the setting of a known syphilis infection. [3] [19]
Centers for Disease Control and Prevention (CDC)-approved standard tests include the VDRL test (a slide test), the rapid plasma reagin (RPR) test (a card test), the unheated serum reagin (USR) test, and the toluidine red unheated serum test (TRUST). [2] These have mostly replaced the first nontreponemal test, the Wassermann test. [citation needed]
One source states that the specificity of the test is high, virtually 100%, [7] Another source states that a number of other conditions can cause false positives. [5] Rarely, however, a false positive heterophile antibody test may result from systemic lupus erythematosus, toxoplasmosis, rubella, lymphoma and leukemia.
Regular testing for HIV is part of pregnancy these days, which bumps up the chance you might get a false-positive result. Experts explain why that can happen. Pregnant People Can Have a False ...
A version of this story appeared in CNN’s What Matters newsletter. To get it in your inbox, sign up for free here.. We will not know the extent or the success of President Donald Trump’s purge ...
Replacement tests such as the VDRL test and the RPR test, initially based on flocculation techniques (Hinton), have been shown to produce far fewer false positive results. [citation needed] Indeed, the "biologic false positives" of modern tests usually indicate a serious alternate condition, often an autoimmune disease.