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Daniel Pearl (October 10, 1963 – February 1, 2002) was an American journalist who worked for The Wall Street Journal. On January 23, 2002, he was kidnapped by Islamist militants while he was on his way to what he had expected would be an interview with Pakistani religious cleric Mubarak Ali Gilani in the city of Karachi.
The more common side effects include fever, gastrointestinal disturbances, rashes, and immunological reactions. Taking rifampicin usually causes certain bodily fluids, such as urine, sweat, and tears, to become orange-red in color, a benign side effect that nonetheless can be frightening if it is not expected.
Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis. [1] It is a fixed dose combination of isoniazid and rifampicin (rifampin). [1] It is used together with other antituberculosis medication. [1] It is taken by mouth. [1] It is on the World Health Organization's List of Essential Medicines. [2]
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.
In non-resistant TB, rifampin binds the beta subunit of RNA polymerase and disrupts transcription elongation. Mutation in the rpoB gene changes the sequence of amino acids and eventual conformation, or arrangement, of the beta subunit. In this case, rifampin can no longer bind or prevent transcription, and the bacterium is resistant. [19] [20]
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
Common side effects include nausea and loss of appetite. [5] Other side effects include liver inflammation , methemoglobinemia , [ 6 ] and a number of types of skin rashes. [ 3 ] While the safety of use during pregnancy is not entirely clear some physicians recommend that it be continued in those with leprosy. [ 3 ]
While pseudomonas can develop resistance to rifampin, I cannot find a reference for the idea that it is inherently resistant -- in fact, I actually ended up on this page because I have been reading articles detailing surprisingly good outcomes in pseudomonas aeruginosa induced osteomyelitis obtained by adding rifampin to other antibiotics.