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Grape fruit juice: Grapefruit juice suppresses enzymes metabolizing calcium channel antagonists (cytochrome P450) and reduces the clearance. Thus, there is a possibility that blood concentration of the drug may increase and the anti-hypertensive effect is enhanced.
It is a calcium channel blocker of the dihydropyridine class. ... Grapefruit juice also increases nisoldipine concentrations by inhibiting CYP3A4. [3] Pharmacology
Drugs that decrease breaking down of carbamazepine or otherwise increase its levels include erythromycin, [32] cimetidine, propoxyphene, and calcium channel blockers. [18] Grapefruit juice raises the bioavailability of carbamazepine by inhibiting the enzyme CYP3A4 in the gut wall and in the liver. [5]
Still, says Peterson, "most people won't have issues unless they eat large quantities of grapefruit, drink more than one liter per day of grapefruit juice, or consistently eat or drink grapefruit.
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
Zalicus Presents Data on Novel, Oral, N- and T-Type Calcium Channel Blockers for the Treatment of Pain Preclinical Data on Z160 and Z944 Presented at the American Pain Society 2013 Annual Meeting ...
One whole grapefruit, or a small glass (200 mL, 6.8 US fl oz) of grapefruit juice, can cause drug overdose toxicity. [1] Fruit consumed three days before the medicine can still have an effect. [ 5 ] The relative risks of different types of citrus fruit have not been systematically studied. [ 1 ]
Orange or grapefruit juice The citrus juices are very high in vitamin C, so they’re pretty popular, Young says. She’s partial to grapefruit juice, but cautions people to be aware of its ...